In the pharmaceutical industry, the production of water injections (penicillin, etc.) and large infusion solutions (such as amino acids, etc.), powder injections, lyophilized agents and oral liquid preparations all face a product oxidation problem. How to extend the shelf life of the liquid medicine and There are no safety risks for users, which has always been a concern for pharmaceutical manufacturers.

The emergence of nitrogen as an inactive inert gas soon made people realize its broad application value in the pharmaceutical industry. By obtaining high-purity nitrogen, which have significant effects in prolonging the oxidation of synthetic drugs, isolating pollution in bioengineering, and protecting Chinese herbal medicines from moth and corrosion.

In the past, most of the nitrogen used in pharmaceuticals came from industrial nitrogen in cylinders or liquid nitrogen vaporized into standard nitrogen. However, with the development of pharmaceutical machinery, the emergence of high-purity nitrogen generators has provided more convenience for the use of nitrogen in pharmaceuticals. The working principle of the nitrogen generator is molecular sieve pressure swing adsorption, which uses carbon molecular sieves as adsorbents to physically separate high-purity nitrogen from the air. The core process uses two adsorption towers, one is responsible for adsorption and nitrogen production, and the other is responsible for depressurization and regeneration. It is automatically controlled by the program. The two towers work alternately in cycles to achieve continuous production of high-quality nitrogen. This method of nitrogen acquisition has low infrastructure requirements, easy maintenance of equipment, high degree of automation, and low nitrogen cost. It is favored by many small and medium-sized nitrogen-using enterprises.

However, there is still a little difference between pharmaceutical nitrogen generators and ordinary nitrogen generators; mainly because pharmaceutical nitrogen generators need to meet the international standards of the pharmaceutical industry, that is, GMP certification, and the parts that come into contact with drugs or liquids are made of stainless steel and meet nitrogen dust removal, odor removal, sterilization and other requirements. The equipment and pipelines need to be made of stainless steel and degreased and purified. The nitrogen outlet of the equipment is equipped with purification, filtration and sterilization devices. In addition, both the nitrogen production principle and the production process are the same as those of ordinary nitrogen generators.